This post will discuss the liquid-liquid extraction techniques and the same solvent and liquid-liquid extraction techniques. Adjusting the pH and ionic strength in the aqueous phase changes the extraction efficiency. For phenyl ureas, triazoles, amides, carbamates, benzimidazoles, dichlorotriazine, ethyl acetate, dichloromethane and their combinations are excellent extraction solvents. All rights reserved.Liquid-liquid extraction is the most common approach for isolating herbicides from water and biological fluid samples. Thus, the proposed CF-SLE method is promising for the routine sample preparation of protein-rich aqueous samples prior to instrumental analysis.Ĭotton fiber Glucocorticoids Milk Plasma Protein-rich aqueous sample Supported liquid extraction.Ĭopyright © 2023 Elsevier B.V. This system is simple, low-cost, reproducible, and easy to automate. Coupled with liquid chromatography-tandem mass spectrometry, a sensitive quantification method was established with excellent linearity (R 2 > 0.991) as well as good accuracy (85.7-117.3%) and precision (<14.3%). As a proof-of-concept study, the glucocorticoids in milk and plasma were extracted with satisfactory extraction recoveries. Emulsification and centrifugation steps involved in the classic liquid-liquid extraction were avoided. Extraction used a simple two-step protocol: protein-rich aqueous sample loading and elution. The cost of the extraction device was less than 0.5 CNY, and the costly syringe tube could be easily reused to decrease the cost further. No filter frits were required due to the fibrous feature of the cotton fibers. Natural cotton fiber was directly loaded into a syringe tube to conveniently construct the extraction device. This study proposed a novel cotton fiber-supported liquid extraction (CF-SLE) method for convenient sample preparation. Electronic address: aqueous samples such as milk and plasma usually require complex sample preparation steps prior to instrumental analysis. Electronic address: 4 Physics Diagnostic Division, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. 3 School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases of Henan Province, Zhengzhou, 450001, China National Key Laboratory of Cotton Bio-breeding and Integrated Utilization, Zhengzhou University, Zhengzhou 45001, China.Electronic address: 2 School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: 1 School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases of Henan Province, Zhengzhou, 450001, China National Key Laboratory of Cotton Bio-breeding and Integrated Utilization, Zhengzhou University, Zhengzhou 45001, China. 1 School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases of Henan Province, Zhengzhou, 450001, China National Key Laboratory of Cotton Bio-breeding and Integrated Utilization, Zhengzhou University, Zhengzhou 45001, China.
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